MKC9989 ( —— )

产品货号. M26299 CAS No. 1338934-20-5

COA

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HNMR

HPLC

MSDS

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产品名称

MKC9989
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM.
产品描述

MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM.(In Vitro):MKC9989, significantly stabilizes the RIDD target CD59 mRNA when co-administered with thapsigargin relative to thapsigargin treatment alone and modestly increases levels of CD59 mRNA in non-stressed cells, the latter likely reflects the inhibition of baseline RIDD activity. In contrast to effects on XBP1 splicing, MKC9989 moderately stabilizes CD59 levels when administered 2 hour post treatment with thapsigargin..
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靶点

Other Targets
受体

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研究领域

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适应症

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1.Brent R. StockwellWan Seok YangRohitha SriRamaratnam. Oncogenic-RAS-signal dependent lethal compounds.US8546421B1

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