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MK6-83
CAS No. 1062271-24-2
MK6-83 ( MK6 83 | MK683 )
产品货号. M27779 CAS No. 1062271-24-2
MK6-83 是瞬时受体电位通道 ML3 激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥332 | 有现货 |
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| 5MG | ￥535 | 有现货 |
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| 10MG | ￥786 | 有现货 |
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| 25MG | ￥1596 | 有现货 |
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| 50MG | ￥2795 | 有现货 |
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| 100MG | ￥4771 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MK6-83
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MK6-83 是瞬时受体电位通道 ML3 激动剂。
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产品描述MK6-83 is the transient receptor potential channel ML3 agonist.(In Vitro):MK6-83(0.2-30 μM) shows no signs of cytotoxicity. Administration of 0-10 μM MK6-83 for 24 hours is efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells and has no significant effect on lysosomes isolated from TRPML1-/- fibroblasts.
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体外实验Cell Viability Assay.Cell Line:Lysosomes isolated from fibroblast cell lines derived from MLIV patients carrying either the F408D, the R403C or the V446L mutation.Concentration:0-10 μM.Incubation Time:24 h.Result:Efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells.
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体内实验——
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同义词MK6 83 | MK683
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通路Membrane Transporter/Ion Channel
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靶点TRP/TRPV Channel
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受体Akt| mTOR| Microtubule/Tubulin| Apoptosis
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研究领域——
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适应症——
化学信息
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CAS Number1062271-24-2
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分子量336.47
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分子式C16H20N2O2S2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 25 mg/mL (74.30 mM)
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SMILESCc1ccc(s1)S(=O)(=O)Nc1ccccc1N1CCCCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Jason E Faris,et al. A phase 2 study of oral MKC-1, an inhibitor of importin-β, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer.Invest New Drugs. 2012 Aug;30(4):1614-20.
