MK-0752

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的 γ-分泌酶抑制剂，在人 SH-SY5Y 细胞中显示 Aβ40 的剂量依赖性减少，IC50 为 5 nM。

A potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells; Notch signaling inhibitor.Breast Cancer Phase 2 Clinical.

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Animal Model:Male rhesus monkeysDosage:60-240 mg/kg Administration:P.o.Result:Generation of new Aβ was partially blocked with administration of 60 mg/kg, and nearly completely blocked at the 240 mg/kg dose as indicated by the dose-dependent decrease in the amount of 13C6-leucine-labeled Aβ.

MK0752 | MK 0752

Wnt/Notch/Hedgehog

γ-secretase

Aβ

Cancer

Breast Cancer

471905-41-6

442.9038

C21H21ClF2O4S

>98% (HPLC)

10 mM in DMSO

O=C(O)CC[C@H]1CC[C@](C2=CC(F)=CC=C2F)(S(=O)(C3=CC=C(Cl)C=C3)=O)CC1

Cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-

(-20℃)

With Ice Pack

≥ 2 years