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MDL-800
CAS No. 2275619-53-7
MDL-800 ( MDL800 )
产品货号. M13621 CAS No. 2275619-53-7
MDL-800 (MDL800) 是一种一流的选择性细胞活性 SIRT6 变构激活剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥972 | 有现货 |
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| 10MG | ￥1442 | 有现货 |
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| 25MG | ￥2438 | 有现货 |
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| 50MG | ￥3653 | 有现货 |
|
| 100MG | ￥5370 | 有现货 |
|
| 500MG | ￥11259 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MDL-800
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MDL-800 (MDL800) 是一种一流的选择性细胞活性 SIRT6 变构激活剂。
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产品描述MDL-800 (MDL800) is a first-in-class, selective, cellular active SIRT6 allosteric activator, increases SIRT6 deacetylation activity with EC50 of 10.3 uM in RHKK-ac-AMC and FDL assays; dramatically enhanced SIRT6 deacetylation activity by more than 22-fold, displays no activity toward SIRT1, SIRT3, SIRT4, and HDAC1-11 at 50-100 uM, as well as >10-fold selectivity toward SIRT2, SIRT5, and SIRT7; activates SIRT6 through a surface allosteric site induces H3K9ac and H3K56ac deacetylation and represses proliferation of HCC cells (IC50=23.3 uM); inhibits xenograft tumor growth of HCC cells in immunocompromised mice by activating the deacetylase activity of SIRT6.
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体外实验——
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体内实验——
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同义词MDL800
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通路Chromatin/Epigenetic
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靶点Sirtuin
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受体Sirtuin
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研究领域——
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适应症——
化学信息
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CAS Number2275619-53-7
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分子量626.289
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分子式C21H16BrCl2FN2O6S2
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(OC)C1=CC(NS(=O)(C2=CC(Cl)=CC(Cl)=C2)=O)=CC=C1S(=O)(NC3=CC(Br)=C(F)C=C3C)=O
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化学全称methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-((3,5-dichlorophenyl)sulfonamido)benzoate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Huang Z, et al. Nat Chem Biol. 2018 Oct 29. doi: 10.1038/s41589-018-0150-0.
