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MD2-IN-1
CAS No. 111797-22-9
MD2-IN-1 ( MD2-IN-1; MDK7229; MDK 7229; MDK 7229. )
产品货号. M17145 CAS No. 111797-22-9
MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1450 | 有现货 |
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| 10MG | ￥2398 | 有现货 |
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| 25MG | ￥4301 | 有现货 |
|
| 50MG | ￥6221 | 有现货 |
|
| 100MG | ￥8667 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MD2-IN-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).
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产品描述MDK7229, also known as MD2-IN-1 is a MD2 (Myeloid differentiation protein 2) inhibitor. MDK7229 has CAS#111797-22-9. For easy communication, we use its last 4 digit of CAS for name. MDK7229 locked the LPS-induced activation of TLR4/MD2 -downstream pro-inflammatory MAPKs/NF-κB signaling pathways. In a rat model with ALI induced by intracheal LPS instillation, administration MDK7229 exhibited significant protective effect against ALI, accompanied by the inhibition of TLR4/MD2 complex formation in lung tissues.
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同义词MD2-IN-1; MDK7229; MDK 7229; MDK 7229.
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通路Others
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靶点Other Targets
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受体Myeloid differentiation protein 2(MD2)
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研究领域Inflammation/Immunology
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适应症——
化学信息
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CAS Number111797-22-9
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分子量358.39
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分子式C20H22O6
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纯度98%
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溶解度DMSO : 50 mg/mL 139.51 mM; H2O : < 0.1 mg/mL
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SMILESCOc1ccc(cc1OC)C(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
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化学全称(E)-1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Zhang Y, et al. Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury. Sci Rep. 2016 Apr 27;6:25130.
产品手册
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