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MCU-i11
CAS No. 902903-59-7
MCU-i11 ( —— )
产品货号. M28985 CAS No. 902903-59-7
MCU-i11 是一种新型 MCU 负调节剂，可结合 MICU1 并损害肌肉细胞生长。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3540 | 有现货 |
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| 10MG | ￥5233 | 有现货 |
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| 25MG | ￥7995 | 有现货 |
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| 50MG | ￥11178 | 有现货 |
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| 100MG | ￥15066 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MCU-i11
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MCU-i11 是一种新型 MCU 负调节剂，可结合 MICU1 并损害肌肉细胞生长。
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产品描述MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.(In Vitro):Mitochondrial Ca2+ uptake in mouse embryonic fibroblasts (MEFs), MDA-MB-231, and HEK293T cell lines were measured upon treatment with 10 μM compound. MCU-i11 reduced mitochondrial Ca2+ uptake in all tested cell lines, indicating the existence of a conserved mechanism. MCU-i11 had no effect on cell viability.
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体外实验——
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体PI3Kδ
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研究领域——
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适应症——
化学信息
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CAS Number902903-59-7
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分子量532.61
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分子式C28H28N4O5S
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纯度>98% (HPLC)
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溶解度——
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SMILESCCOC1=CC=C(NC(=O)CN2C3=C(C4=C(CN(CC4)C(C)=O)S3)C(=O)N(CC3=CC=CC=C3)C2=O)C=C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Li F, et al. Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63(22):13973-13993.
产品手册
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