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MCU-i11

CAS No. 902903-59-7

MCU-i11 ( —— )

产品货号. M28985 CAS No. 902903-59-7

MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥3540 有现货
10MG ¥5233 有现货
25MG ¥7995 有现货
50MG ¥11178 有现货
100MG ¥15066 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    MCU-i11
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
  • 产品描述
    MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.(In Vitro):Mitochondrial Ca2+ uptake in mouse embryonic fibroblasts (MEFs), MDA-MB-231, and HEK293T cell lines were measured upon treatment with 10 μM compound. MCU-i11 reduced mitochondrial Ca2+ uptake in all tested cell lines, indicating the existence of a conserved mechanism. MCU-i11 had no effect on cell viability.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    PI3Kδ
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    902903-59-7
  • 分子量
    532.6
  • 分子式
    C28H28N4O5S
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    CCOC1=CC=C(NC(=O)CN2C3=C(C4=C(CN(CC4)C(C)=O)S3)C(=O)N(CC3=CC=CC=C3)C2=O)C=C1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Li F, et al. Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63(22):13973-13993.
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