MC1742

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MC1742 是一种有效的 HDAC 抑制剂，对 HDAC1、HDAC2、HDAC3、HDAC6、HDAC8、HDAC10 和 HDAC11 的 IC50 分别为 0.1 μM、0.11 μM、0.02 μM、0.007 μM、0.61 μM、0.04 μM 和 0.1 μM。MC1742 可以增加乙酰 - H3 和乙酰微管蛋白的水平，抑制癌症干细胞 (CSC) 的生长。MC1742 可诱导肉瘤干细胞生长停滞、凋亡 (apoptosis) 和分化。

MC1742 is a potent HDAC inhibitor, with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC.

MC1742 (compound 1) (0.5 and 2 μM; 24 hours) increases acetylation in a dose-dependent manner, observable as punctuate nuclear staining of acetyl-histone H3.MC1742 (0.5, 1 and 2 μM; 24, 48 and 72 hours) significantly induces apoptosis of all CSC cultures.MC1742 (0.025-0.5 μM; 14 days) enhances bone nodule formation in a significantdose-dependent manner.Immunofluorescence Cell Line:Sarcoma cancer stem cells Concentration:0.5 and 2 μM Incubation Time:24 hours Result:Increased acetylation in a dose-dependent manner, observable as punctuate nuclear staining of acetyl-histone H3.Apoptosis Analysis Cell Line:Sarcoma cancer stem cells Concentration:0.5, 1 and 2 μM Incubation Time:24, 48 and 72 hours Result:Significantly induced apoptosis of all CSC cultures.Cell Differentiation Assay Cell Line:Sarcoma cancer stem cells Concentration:0.025, 0.05, 0.1 and 0.5 μM Incubation Time:14 days Result:Successfully enhanced bone nodule formation in a significantdose-dependent manner.

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Other Targets

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1776116-74-5

395.47

C21H21N3O3S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 200 mg/mL (505.73 mM; 超声助溶 )

S(CCCCC(NO)=O)C=1NC(=CC(=O)N1)C2=CC=C(C=C2)C3=CC=CC=C3

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(-20℃)

With Ice Pack

≥ 2 years