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MC-1575
CAS No. ——
MC-1575 ( MC1575 )
产品货号. M17051 CAS No. ——
MC-1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MC-1575
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MC-1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A.
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产品描述MC-1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A, displays >70-fold selectivity over HD1-B; exhibits a dose-dependent antiproliferative effect and induces cell cycle arrest although this blockade occurred at a different level than TSA; increases p21(waf1/CIP1) mRNA levels and induces ERbeta gene expression; also suppress IL-8 expression in human melanoma cells.
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同义词MC1575
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量329.78
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分子式C18H16ClNO3
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称(E)-3-(3-((E)-3-(3-chlorophenyl)-3-oxoprop-1-en-1-yl)-5-methylcyclopenta-1,3-dien-1-yl)-N-hydroxyacrylamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mai A, et al. J Med Chem. 2005 May 5;48(9):3344-53.
2. Duong V, et al. Mol Cancer Res. 2008 Dec;6(12):1908-19.
3. Venza I, et al. Pigment Cell Melanoma Res. 2013 Mar;26(2):193-204.
2. Duong V, et al. Mol Cancer Res. 2008 Dec;6(12):1908-19.
3. Venza I, et al. Pigment Cell Melanoma Res. 2013 Mar;26(2):193-204.
产品手册
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