MAO-B-IN-5

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MAO-B-IN-5 是一种有效的、选择性和具有口服活性的 MAO-B 抑制剂，IC50 值为 0.204 μM。MAO-B-IN-5 具有研究帕金森病 (PD) 的潜力。

MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 μM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD).

MAO-B-IN-5 (compound D0) (Sf9 cells) shows inhibitory activities towards MAO with the IC50s of 34.190 μM and 0.204 μM for MAO-A and MAO-B, respectively.

MAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%).Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats.SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o..Animal Model:SD rats Dosage:1, 5 mg/kg Administration:1 mg/kg, i.v.; 5 mg/kg, p.o.Result:Showed oral bioavailability in rats (F=16.3%).

——

Others

Other Targets

Others

——

——

849909-77-9

328.38

C19H21FN2O2

>98% (HPLC)

——

C(N1[C@H](C(N)=O)CCC1)C2=CC=C(OCC3=CC(F)=CC=C3)C=C2

——

(-20℃)

With Ice Pack

≥ 2 years