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MAC-545496
CAS No. 838810-96-1
MAC-545496 ( ―― )
产品货号. M21764 CAS No. 838810-96-1
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). MAC-545496 displays strong binding affinity to the full-length GraR protein (Kd ● 0.1 nM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
生物学信息
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产品名称MAC-545496
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). MAC-545496 displays strong binding affinity to the full-length GraR protein (Kd ● 0.1 nM).
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产品描述MAC-545496 potently synergizes with Cefuroxime; concentrations as low as 0.03 ┢g/mL (~75 nM) lowers the ┑-lactam MIC from 512 to 8 ┢g/mL against S. aureus USA300. MAC545496 also synergizes with Cefuroxime and Oxacillin against a collection of ten S. aureus clinical isolates. In addition, MAC-545496 potentiates the effect of Cefuroxime against representatives of other circulating MRSA strains such as USA100, USA400 and USA500 to different extents, with the exception of CMRSA4, a USA200/EMRSA16 isolate. MAC-545496 also synergizes with the antimicrobial peptides colistin and polymyxin B.MAC-545496 shows inhibition of mprF expression in a concentration-dependent manner; the IC50 value is 0.0376 ┢g/mL.MAC-545496 also inhibits the citrateinduced biofilm formation in the wild type in a concentration dependent manner.
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同义词――
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通路GPCR/G Protein
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靶点Antibacterial
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受体――
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研究领域――
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适应症――
化学信息
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CAS Number838810-96-1
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分子量419.89
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分子式C18H18ClN5O3S
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纯度>98% (HPLC)
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溶解度DMSO : 250 mg/mL (595.39 mM; Need ultrasonic)
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SMILESO=C(NC(NC1=NC=C(Cl)C=C1)=S)C2=CC=C(N3CCCCC3)C([N+]([O-])=O)=C2
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化学全称――
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. El-Halfawy OM, et al. Discovery of an antivirulence compound that reverses ┑-lactam resistance in MRSA. Nat Chem Biol. 2019 Nov 25.
