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M435-1279
CAS No. 1359431-16-5
M435-1279 ( —— )
产品货号. M37630 CAS No. 1359431-16-5
M435-1279 是 UBE2T 抑制剂。M435-1279 通过阻断 UBE2T 介导的 RACK1 降解来抑制 Wnt/β-catenin 信号通路的过度激活。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥401 | 有现货 |
|
| 5MG | ￥589 | 有现货 |
|
| 10MG | ￥937 | 有现货 |
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| 25MG | ￥1744 | 有现货 |
|
| 50MG | ￥2604 | 有现货 |
|
| 100MG | ￥3596 | 有现货 |
|
| 200MG | ￥5064 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称M435-1279
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述M435-1279 是 UBE2T 抑制剂。M435-1279 通过阻断 UBE2T 介导的 RACK1 降解来抑制 Wnt/β-catenin 信号通路的过度激活。
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产品描述M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1.
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体外实验Cell Viability Assay Cell Line:HGC27, AGS, and MKN45 cells Concentration:0, 2, 4, 8, 16, 31 μM Incubation Time:48?h Result:Inhibited the cell growth. Cell Viability Assay Cell Line:HGC27, AGS, and MKN45 cells Concentration:0, 4, 8, 12, 16, 20 μM Incubation Time:Result:Inhibited the cell viability with IC50s of 16.8, 11.88, 6.93, 7.76 μM in GES-1, HGC27, MKN45, AGS cells, respectively.
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体内实验Animal Model:BALB/C nude mice CDX model (MKN45 tumor size: 75–100?mm3) Dosage:5?mg/kg/day Administration:Intratumor injection for 18 days Result:Slowed the tumor growth.Induced higher RACK1 proteins expression, and lower Ki-67 and β-catenin proteins expression in intratumor tumors.
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同义词——
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通路Proteasome/Ubiquitin
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靶点E1
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受体E1/E2/E3 Enzyme
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研究领域——
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适应症——
化学信息
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CAS Number1359431-16-5
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分子量419.47
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分子式C18H17N3O5S2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 50 mg/mL (119.20 mM; 超声助溶 )
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SMILESNS(=O)(=O)c1ccc(NC(=O)c2c(O)c3c4CCCCc4sc3[nH]c2=O)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Yu Z, et al. A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination. Oncogene. 2021 Feb;40(5):1027-1042. doi: 10.1038/s41388-020-01572-w. Epub 2020 Dec 15. Erratum in: Oncogene. 2021 Apr;40(14):2622-2623.?
