Antagonist G ( ——— )

产品货号. M41872 CAS No. 115150-59-9

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产品名称

Antagonist G
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Antagonist G是有效的后叶加压素 (vasopressin) 的拮抗剂。Antagonist G 也是弱的 GRP 和缓激肽的弱拮抗剂。Antagonist G 可诱导 AG-1 的转录，是癌细胞对化疗增敏。
产品描述

Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy.
体外实验

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体内实验

Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells.Antagonist G activates JNK1 in SCLC cells.Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%.Cell Viability Assay Cell Line:SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells.Concentration:0-100 μM.Incubation Time:24 h.
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研究领域

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适应症

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1. P J Woll, et al. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 1990 Jul 1;50(13):3968-73.?

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