GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intraperitoneal glucose tolerance, insulin sensitivity, and glucose response to feeding in ob/ob mice.

LSP-249 是一种血浆激肽释放酶抑制剂，正在研究治疗血管性水肿，细胞内 EC50 小于 100 nM。

OTs-C6-OBn 是一种基于烷基链的 PROTAC 连接体，可用于合成 PROTAC SGK3 degrader-1。