VK-II-86 是一种非 β 阻断卡维地洛类似物。它可以防止哇巴因引起的心脏毒性。

Cell-permeable calmodulin (CaM) antagonist that binds to the EF-hand/Ca2+-binding site. CALP2 has been demonstrated to inhibit CaM-dependant phosphodiesterase activity and increase intracellular Ca2+ concentrations by modulating Ca2+-channel activity. CALP2 has also been shown to be a potent activator of alveolar macrophages.

Poricoic Acid A 是一种具有抗肿瘤活性的天然产物。它还通过调节 Gas6/AxlNFκB/Nrf2 轴增强褪黑激素对 AKI 向 CKD 转变的抑制作用。