[D-Pro2,D-Trp6,8,Nle10]-Neurokinin B ( ——— )

产品货号. M41434 CAS No. 109212-72-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

[D-Pro2,D-Trp6,8,Nle10]-Neurokinin B
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B 是 Neurokinin B (Neurokinin Receptor) 的竞争性拮抗剂，pA2 为 5.5，对 Substance P 或 Neurokinin A 没有影响。
产品描述

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A.
体外实验

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B (1 mg/kg i.v.) significantly reduces Substance P- and Neurokinin B- but not acetylcholine- or Neurokinin A-induced salivation. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B lowers blood pressure in anesthetized rats by 35 to 40%.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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1. H I Jacoby, et al. Differentiation of multiple neurokinin receptors in the guinea pig ileum. Life Sci. 1986 Nov 24;39(21):1995-2003. ?

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