Atrial Natriuretic Peptide (126-149) (rat)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Auriculin A 是一种合成的心房利钠因子 (ANF)，具有血流动力学作用。Auriculin A 拮抗犬肾血管收缩，影响兔后肢血流灌注压、心率、全身血压的动脉压力反射控制。

Auriculin A is a synthetic atrial?natriuretic?factor?(ANF) with hemodynamic effect. Auriculin A antagonizes renal vasoconstriction in the dog, and influences on arterial baroreflex control of heart rate, systemic blood pressure, and perfusion pressure in the hind limb (perfused at constant flow) in rabbits.

Auriculin A (0.3 μg/min/kg; i.v.; for 30 min) antagonizes renal vasoconstriction in the dog.Auriculin A (2 μg/kg prime, 0.2 μg/kg/min; i.v.; for 45 min) influences on arterial baroreflex control of heart rate, systemic blood pressure, and perfusion pressure in the hind limb (perfused at constant flow) in rabbits.Animal Model:Female mongrel dogs used in early clamp experiments (15-20 kg, anesthetized with 30 mg/kg pentobarbital sodium i.v.)Dosage:0.3 μg/min/kg Administration:Intravenous injection; last for 30 min Result:Increased glomerular filtration rate (GFR) 16±4% and Na excretion (UNa V) 261±63%, whereas it decreased urine osmolality (Uosm) 36±7% without changing free water clearance. Also increased diuresis (V) and kaliuresis (UKV). Animal Model:New Zealand white male rabbits (3-3.5 kg, anesthetized with 50 mg/kg Chloralose and 500 mg/kg Urethane i.v.) Dosage:0.5 μg/kg prime, 0.05 μg/kg/min; 2 μg/kg prime, 0.2 μg/kg/min; 4 μg/kg prime, 0.4 μg/kg/min; 8 μg/kg prime, 0.8 μg/kg/min Administration: Intravenous injection; last for 30-60 min Result:Significantly reduced mean blood pressure and increased mean perfusion pressure at 4 μg/kg prime, 0.4 μg/kg/min dose, while heart rate did not change.

———

———

Others

Other Targets

———

———

———

91421-87-3

2542.86

C104H168N38O33S2

>98% (HPLC)

———

———

———

(-20℃)

With Ice Pack

≥ 2 years