MSH Release Inhibiting Factor, amide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MIF-1 (Melanostatin) 是一种内源性的脑肽，是一种有效的多巴胺受体变构调节剂。MIF-1 抑制黑色素形成。MIF-1 阻断阿片受体激活的作用，从而调节吗啡的镇痛作用和应激诱导镇痛 (SIA)。MIF-1 直接通过血脑屏障 (BBB) 从血液进入中枢神经系统。

MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB).

MIF-1 (Melanostatin, 1 mg/kg; i.p.; once, for 1 hour; male Wistar rats) modulates the analgesic effects and stress-induced analgesia (SIA).MIF-1 (Melanostatin, 1 mg/kg; i.p.; daily, for 8 weeks; Sprague-Dawley rats) attenuates spiroperidol-induced impairment of development of striatal dopamine D2 receptors in rats.Animal Model:Male Wistar rats Dosage:1 mg/kg Administration:Intraperitoneal injection; once, for 1 hour Result:Decreased the analgesic effect. Increased the pain threshold for at least 1 h.Animal Model:Sprague-Dawley rats Dosage:1 mg/kg Administration:Intraperitoneal injection; daily, for 8 weeks Result:Attenuated the ontogenic impairment of striatal D2 receptors that was produced by spiroperidol treatment.

MIF-1 (Melanostatin, 1 μM) provokes a reversible hyperpolarization and a suppression of spontaneous action potentials.

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Others

Other Targets

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2002-44-0

284.36

C13H24N4O3

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years