(Glu2)-TRH

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(Glu2)-TRH 是一种代谢稳定的 Thyrotropin-releasing hormone (TRH) 类似物，是小鼠大脑中 TRH 胆碱能作用的负调节剂。(Glu2)-TRH 显着减弱 TRH 诱导的海马细胞外乙酰胆碱释放。(Glu2)-TRH 不被甲状腺解放酶代谢。(Glu2)-TRH 在中枢神经系统中表现出神经保护、抗抑郁、抗惊厥作用。

(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS.

(Glu2)-TRH (1-100 μmol/kg; 静脉注射) 剂量依赖性地减弱 TRH 诱导的兴奋作用。(Glu2)-TRH (10 μmol/kg; 静脉注射) 在戊巴比妥 (60 mg/kg; 腹腔) 前 10 分钟给药，与载体处理组相比，睡眠时间减少了大约 20%。Animal Model:Male Swiss-Webster mice (30 g)Dosage:1, 2, 5, 10, 15, 25, 50, 100 μmol/kg Administration:IV; 10 min before Pentobarbital (60 mg/kg, i.p.) Result:Dose-dependently attenuated TRH-induced (10 μmol/kg; iv) analeptic action.

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Others

Other Targets

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85541-78-2

354.38

C15H22N4O6

>98% (HPLC)

DMSO : 100 mg/mL (282.20 mM; ultraphonic; )

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(-20℃)

With Ice Pack

≥ 2 years