α-Helical CRF (12-41)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

a-Helical Corticotropin Releasing Factor (12-41) 是一种 30 个氨基酸长度的，促肾上腺皮质激素释放因子/激素的 α 螺旋类似物。促肾上腺皮质激素释放因子 (CRF) 是一种下丘脑激素，能刺激肾上腺皮质激素 (ACTH) 的分泌。a-Helical Corticotropin Releasing Factor (12-41) 则会抑制这种刺激作用。

a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect.

a-Helical Corticotropin Releasing Factor (12-41) (15-150 μg; s.c.; isolated for 30 or 60 min) suppresses the active behavioral response characteristic of guinea pig pups to brief isolation in novel surroundings.Animal Model:Guinea pig pups (20-26 days old and ) Dosage:15, 50, 150 μg per animalAdministration:Subcutaneous injection; isolated in novel surroundings for 30 min or 60 min.Result:Resulted pups vocalized more and exhibited more locomotor activity in 20- to 26-day-old pups. Increased levels of vocalizing in isolated 4- to 6-day-old pups at 50 μg dose, though no changes were seen in locomotor activity.

a-Helical Corticotropin Releasing Factor (0.3 nM; 5-min pulses every 40 min alternately) shows the inhibitory effect on stimulated release of immunoreactive ACTH from perifused equine anterior pituitary cells in vitro.. a-Helical Corticotropin Releasing Factor (0.5-5 μM) suppresses CRH-induced ACTH secretion.

———

Others

Other Targets

———

———

———

158535-55-8

3497.08

C152H251N43O47S2

>98% (HPLC)

———

———

———

(-20℃)

With Ice Pack

≥ 2 years