Kisspeptin-13 (human)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Kisspeptin 13 是一种 GPR54 和 GnRH 受体激活剂，是一种内源性的活性异构体。Kisspeptin 13 能增强记忆，可用于阿尔茨海默病的研究。

Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.

Kisspeptin 13 (intracerebroventricular administration; 2 μg/side; once) treatment improves object recognition memory impairment induced by Aβ through activation of GPR54 and GnRH receptor.Animal Model:Male Swiss mice with memory impairment induced by A-beta Dosage:2 μg/side Administration:Intracerebroventricular administration; 2 μg/side; once Result:Facilitated memory formation and prolonged memory retention through activation of the GPR54 and GnRH receptors, and suppressed memory-impairing effect of Aβ through activation of the GPR54.

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Others

Other Targets

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374675-18-0

1626.85

C78H107N21O18

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years