H-Gly-Pro-Arg-OH ( ——— )

产品货号. M39927 CAS No. 47295-77-2

COA

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HNMR

HPLC

MSDS

Handing Instructions

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产品名称

H-Gly-Pro-Arg-OH
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GPR 是一种三氨基酸肽。GPR 可以通过抑制 caspase-3/p53 依赖性细胞凋亡来拯救培养的大鼠海马神经元免受 Aβ 诱导的神经元死亡。GPR 可用于阿尔茨海默病（AD）的研究。
产品描述

GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).
体外实验

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体内实验

GPR (1-100 μM; 24 h, 48 h) prevented Aβ-mediated increase in lactate dehydrogenase (LDH) release. GPR (50 μM; 24 h, 48 h) prevents Ah-mediated inhibition of neuronal MTT reduction.GPR (50 μM; 3 days) prevents Aβ-mediated increase in p53-positive cells. Apoptosis Analysis Cell Line:p53-positive cells Concentration:50 μM Incubation Time:3 days Result:Inhibited Ah-induced increase in numbers of p53-positive neurons.
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