Apelin-12 (human, bovine, mouse, rat)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Apelin-12 是多肽中最有效的 C 端片段之一，对孤儿受体 APJ 受体具有很高的亲和力。Apelin-12 参与体液平衡的调节和摄食的中枢控制。Apelin-12 阻断HIV-1通过 APJ 受体进入。Apelin-12 具有神经保护作用。

Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect.

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Apelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse.Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents.Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs.

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Others

Other Targets

HIV-1

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229961-08-4

1422.72

C64H103N21O14S1

>98% (HPLC)

?H2O : ≥ 100 mg/mL (70.29 mM)

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(-20℃)

With Ice Pack

≥ 2 years