L-Ascorbic Acid 2-Phosphate Sesquimagnesium Salt Hydrate (~15% Inorganics)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

L-ascorbic acid 2-phosphate magnesium hydrate 是一种长效的维生素 C 衍生物 (vitamin C derivative)，可以刺激胶原蛋白的表达和形成。L-ascorbic acid 2-phosphate magnesium hydrate 可以作为培养基补充人脂肪干细胞 (hASCs) 的成骨分化。L-ascorbic acid 2-phosphate magnesium hydrate 增加成骨细胞分化过程中 hASC 中的碱性磷酸酶 (ALP) 活性和 runx2A 的表达。

L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate magnesium hydrate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate magnesium hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.

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L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) magnesium hydrate significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc)achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation withEGF and/or insulin does not have any additional effect .L-Ascorbic acid 2-phosphate (50 μM-250 μM) magnesium hydrate is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 μM AsA2-P and 10 nM dexamethasone (Dex), and 250 μM AsA2-P and 5 nM Dex.Cell Proliferation Assay Cell Line:Human corneal endothelial cells (HCECs) Concentration:0.1 mM; 0.3 mM; 1.5 mM Incubation Time:2 to 3 weeks with medium exchange every 2 to 3 days Result:Stimulated HCEC cells growth.

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Others

Other Targets

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1713265-25-8

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>98% (HPLC)

H2O : 5 mg/mL (ultraphonic (<60°C))

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(-20℃)

With Ice Pack

≥ 2 years