β-Amyloid (1-49)

3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial permeability transport pore (MPTP) and nuclear DNA fragmentation.3-Hydroxybakuchiol has antitumor activity resulting from interactions with the ETC, a system that is already deficient in cancer cells.

Kaempferol 3,4'-diglucoside, a flavonol compound, has been isolated from the aqueous methanolic extract of Norway spruce buds. Furthermore, this compound has also been identified in the needles of the Norway spruce.