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JHU-083
CAS No. 1998725-11-3
JHU-083 ( ——— )
产品货号. M39444 CAS No. 1998725-11-3
JHU-083 是 6-diazo-5-oxo-L-norleucine (DON) 的前体，是一种口服有效的，选择性的谷氨酰胺酶 (glutaminase) 拮抗剂，可阻断脑 CD11b+ 细胞和实验性脑疟疾 (ECM) 中的谷氨酰胺酶，导致动物中谷氨酸水平的净降低。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3468 | 有现货 |
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| 10MG | ￥4921 | 有现货 |
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| 25MG | ￥7310 | 有现货 |
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| 50MG | ￥9858 | 有现货 |
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| 100MG | ￥12870 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称JHU-083
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述JHU-083 是 6-diazo-5-oxo-L-norleucine (DON) 的前体，是一种口服有效的，选择性的谷氨酰胺酶 (glutaminase) 拮抗剂，可阻断脑 CD11b+ 细胞和实验性脑疟疾 (ECM) 中的谷氨酰胺酶，导致动物中谷氨酸水平的净降低。
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产品描述JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals.
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体外实验JHU-083 (1.82 mg/kg；口服；每隔一天一次，持续 12 天) 改善由 CSDS 诱导的社交回避行为和快感缺乏样行为。 JHU-083 (1.82 mg/kg；口服) 减弱 CSDS 诱导的前额皮质和海马 CD11b+ 细胞中谷氨酰胺酶活性的增加，但不影响小脑。JHU-083 处理可抑制 CSDS 诱导的 IL-1β 和 TNF-α 表达上调。Animal Model:Male 7-to 8-week-old C57BL/6J (C57) mice (25-30?g) with chronic social defeat stress (CSDS)Dosage:1.82?mg/kg Administration:PO; every other day for 12 days Result:Ameliorated social avoidance behavior and anhedonia-like behavior induced by CSDS.
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体内实验———
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同义词———
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通路Others
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靶点Other Targets
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受体Glutamine
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研究领域———
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适应症———
化学信息
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CAS Number1998725-11-3
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分子量312.37
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分子式C14H24N4O4
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纯度>98% (HPLC)
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溶解度Ethanol : 133.33 mg/mL (426.85 mM; ultraphonic) DMSO : 100 mg/mL (320.14 mM; ultraphonic; ) H2O : 50 mg/mL (160.07 mM; ultraphonic)
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SMILES[C@H](NC([C@H](CC(C)C)N)=O)(CCC(C=[N+]=[N-])=O)C(OCC)=O
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化学全称[C@H](NC([C@H](CC(C)C)N)=O)(CCC(C=[N+]=[N-])=O)C(OCC)=O
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694.?
产品手册
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