SN-38-D3 ( 7-乙基-10-羟基喜树 )

产品货号. M39327 CAS No. 718612-49-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SN-38-D3
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SN-38-d3 是 SN-38 的氘代物。SN-38 (NK012) 是拓扑异构酶 I (Topoisomerase I) 抑制剂伊立替康的活性代谢产物。SN-38 (NK012) 抑制 DNA 合成和 RNA合成的 IC50 分别为 0.077 和 1.3 μM。
产品描述

SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.
体外实验

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体内实验

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
同义词

7-乙基-10-羟基喜树
通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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1. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. ?

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