Physostigmine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Physostigmine (Eserine) 是一种可逆的乙酰胆碱酯酶 (AChE) 抑制剂。Physostigmine 可以透过血脑屏障并刺激中枢胆碱能神经传递。Physostigmine 能逆转阿尔茨海默病转基因小鼠的记忆缺陷。Physostigmine 也是抗胆碱能中毒的解毒剂。

Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning.

Physostigmine (Eserine; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice.Physostigmine (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats. Animal Model:Heterozygous transgenic mice (Tg(+) mice)Dosage:0.03, 0.1, and 0.3 mg/kg Administration:SC; daily for 6 weeks Result:Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.

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毒扁豆碱

Others

Other Targets

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57-47-6

275.35

C15H21N3O2

>98% (HPLC)

DMSO : 50 mg/mL (181.59 mM; ultraphonic; )

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(-20℃)

With Ice Pack

≥ 2 years