Dehydrocurdione

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dehydrocurdione，一种 zedoary 衍生的倍半萜，在 RAW 264.7 巨噬细胞中诱导血红素加氧酶 (HO)-1，一种抗氧化酶。Dehydrocurdione 与 Keap1 相互作用，导致 Nrf2 易位，随后激活 HO-1 E2 增强子。Dehydrocurdione 抑制脂多糖诱导的 NO 释放，NO 是炎症的标志物。抗炎活性。

Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity.

Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis.Dehydrocurdione (200 mg/kg; p.o.; Sprague-Dawley rats) dose-dependently inhibits carrageenan-induced paw edema.Animal Model:Wistar rats Dosage:120 mg/kg Administration:P.o ; daily for 12 days Result:Significantly reduces chronic adjuvant arthritis.

Dehydrocurdione (RAW 264.7 cells) concentration-dependently increases the HO-1 mRNA level for 3 hr and the protein level for 6 hr, and both effects reached significance at a concentration of 100 μM. Dehydrocurdione interacts with Keap, resulting in Nrf2 translocation followed by activation ofthe HO-1 E2 enhancer.Western Blot Analysis Cell Line:RAW 264.7 cells Concentration:100 μM Incubation Time:24 hours Result:Transiently increased the HO-1 protein level, and its effect peaked at 3-6 hr.

去氢莪术二酮

Others

Other Targets

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38230-32-9

234.33

C15H22O2

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years