CC Chemokine Receptor 3 Fragment II

Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.

PF-04937319 是一种葡萄糖激酶激活剂 (EC50 =154.4 μM)。 PF-04937319 保持降血糖功效，同时减轻许多其他葡萄糖激酶激活剂观察到的低血糖风险。 PF-04937319可用于治疗2型糖尿病的研究。