13-Oxyingenol dodecanoat

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

13-Oxyingenol-13-dodecanoate 是一种可从大戟 (Euphorbia kansui) 中分离得到的酯类。13-Oxyingenol-13-dodecanoate 具有抗 HIV-1 活性，EC50 值为 33.7 nM。

13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC50 value of 33.7 nM.13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis.

13-Oxyingenol-dodecanoate (2.5 mg/kg 和 5 mg/kg 腹腔注射两天一次持续 2 周) 对裸鼠皮下注射 H460 的细胞模型可明显抑制异种移植瘤。Animal Model:xenograft model by injecting H460 cells into nude mice Dosage:2.5 mg/kg and 5 mg/kg; every two days for two weeks Administration:Intraperitoneal injection (i.p.)Result:nhibited the growth of transplanted tumors in nude mice and had no significant toxic effects on organ function.

13-Oxyingenol-dodecanoate (0，3.125，6.25，12.5，25 和 50 μM，72 小时) 对降低 A549， H460 和 BEAS-2B 细胞增殖效果良好。13-Oxyingenol-dodecanoate (0，5，10 和 20 μM，72 小时) 可抑制 NSCLC 细胞中抗凋亡蛋白 BCL-2 的表达，增加促凋亡蛋白 BAX 的表达。13-Oxyingenol-dodecanoate (0，5，10 和 20 μM，72 小时) 影响细胞内的氧化还原状态，通过对线粒体膜电位丧失的影响导致A549 和 H460 细胞中引起浓度依赖性线粒体功能障碍。13-Oxyingenol-dodecanoate (0，5，10 和 20 μM，72 小时) 诱导 ATG5 显著上调，p62 降解，LC3 I 向 LC3 II 的剂量依赖性转化，13-Oxyingenol-dodecanoate 诱导 A549 和 H460 细胞的浓度依赖性自噬。13-Oxyingenol-dodecanoate (0，5，10 和 20 μM，72 小时) 增加了 NSCLC 细胞中 ULK1的表达。Cell Viability Assay Cell Line:A549 and H460 cells Concentration:0, 3.125, 6.25, 12.5, 25, and 50 μM Incubation Time:72 h Result:Increased significantly the antitumor activity of A549 and H460 cells.Western Blot Analysis Cell Line:A549 and H460 cells Concentration:0, 5, 10, 20 μM Incubation Time:72 h Result:Induced significant up-regulation of ATG5, degradation of p62, and dose-dependent conversion of LC3 I to LC3 II.

13-O-正十二烷酸巨大戟酯

Others

Other Targets

Others

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54706-70-6

546.745

C32H50O7

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years