Laurotetanine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Laurotetanine ((+)-Laurotetanine) 是一种口服有效的异喹啉类生物碱，可从 Litsea cubeba (Lour.) Pers 的根中提取。Laurotetanine 通过下调 MUC5AC 和 NF-κB 信号通路抑制 IgE、组胺和炎症反应发挥抗哮喘作用。

Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways.

Laurotetanine ((+)-Laurotetanine; 20-60 mg/kg; p.o.; 每天，持续 21 天; SD 大鼠) 通过下调 MUC5AC 和 NF-κB 信号通路发挥抗哮喘作用。Animal Model:Sprague Dawley (SD) rats (180-220g) Dosage:20, 40, and 60 mg/kg Administration:Oral administration; daily, for 21 days Result:Reduced inflammatory cells, including eosinophils, neutrophils, lymphocytes, and macrophages.Decreased inflammatory cytokines viz IL-4, IL-6, IL-13 and increased IFN-γ.Reduced serum IgE and histamine. Decreased MUC5AC expression and increased NF-κB and IκB expression in lung tissues.

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六驳碱

Others

Other Targets

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128-76-7

327.37

C19H21NO4

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years