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Dehydroglyasperin C
CAS No. 199331-35-6
Dehydroglyasperin C ( 去氢粗毛甘草素C )
产品货号. M38178 CAS No. 199331-35-6
Dehydroglyasperin C 是一种异黄酮，是一种有效的 NAD(P)H:氧化醌还原酶 (NQO1) 和 phase 2 酶诱导剂。Dehydroglyasperin C 具有抗氧化、神经保护、癌症化学预防和抗炎活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥8303 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Dehydroglyasperin C
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Dehydroglyasperin C 是一种异黄酮，是一种有效的 NAD(P)H:氧化醌还原酶 (NQO1) 和 phase 2 酶诱导剂。Dehydroglyasperin C 具有抗氧化、神经保护、癌症化学预防和抗炎活性。
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产品描述Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.
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体外实验In ICR mice, Dehydroglyasperin C (5 mg/kg; once) combined with CCl4 shows reduced lipid droplet formation in liver tissue, as assessed by histological examination. Further, DGC demonstrated a slight protective effect against centrilobular injury caused by CCl4 injection, perhaps through suppression of CYP2E1 expression.
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体内实验Dehydroglyasperin C (0.1-1 μM; 24 h) blocks the PDGF-induced progression through the G0/G1 to S phase of the cell cycle, and down-regulates the expression of CDK; 2, cyclin E, CDK4 and cyclin D1. Dehydroglyasperin C significantly attenuates PDGF-stimulated phosphorylation of PDGF receptor-β, phospholipase C-γ1, AKT and extracellular-regulated kinase 1/2, and DGC inhibits cell migration and the dissociation of actin filaments by PDGF.Dehydroglyasperin C (0.1-1 μM; 24 h) treatment significantly decreases PDGF-induced cell number and DNA synthesis in a dose-dependent manner without any cytotoxicity in human aortic smooth muscle cells (HASMC).Cell Cycle Analysis Cell Line:Human aortic smooth muscle cells (HASMC)Concentration:0.1 μM, 0.5 μM, 1 μM Incubation Time:24 hours Result:Blocked the PDGF-induced progression through the G0/G1 to S phase of the cell cycle.Western Blot Analysis Cell Line:Human aortic smooth muscle cells (HASMC).Concentration:0.1 μM, 0.5 μM, 1 μM Incubation Time:24 hours Result:Down-regulated the expression of CDK; 2, cyclin E, CDK4 and cyclin D1.
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同义词去氢粗毛甘草素C
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点Akt
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受体Akt;AP-1;COX;ERK;HO-1;IkB;IKK;JNK;NADPH;NF-κB;Nrf2;p38 MAPK;p65;PI3K;TNF-α
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研究领域———
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适应症———
化学信息
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CAS Number199331-35-6
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分子量354.4
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分子式C21H22O5
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纯度>98% (HPLC)
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溶解度DMSO : 100 mg/mL (282.17 mM; ultraphonic; )
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SMILES———
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化学全称———
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Hyo Jung Kim, et al. Dehydroglyasperin C, a component of liquorice, attenuates proliferation and migration induced by platelet-derived growth factor in human arterial smooth muscle cells. Br J Nutr. 2013 Aug 28;110(3):391-400.?2. Ji Hoon Lee, et al. Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K. Mol Carcinog. 2016 May;55(5):552-62.?3. Ji Yeon Seo, et al. Dehydroglyasperin C isolated from licorice caused Nrf2-mediated induction of detoxifying enzymes. J Agric Food Chem. 2010 Feb 10;58(3):1603-8.?4. Seo, J.Y, et al. Protective effects of dehydroglyasperin c against carbon tetrachloride-induced liver damage in mice. Food Sci Biotechnol 23, 547–553 (2014).
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