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PNU-282987
CAS No. 123464-89-1
PNU-282987 ( ——— )
产品货号. M38006 CAS No. 123464-89-1
PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥364 | 有现货 |
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| 10MG | ￥586 | 有现货 |
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| 25MG | ￥1088 | 有现货 |
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| 50MG | ￥1814 | 有现货 |
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| 100MG | ￥3348 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥645 | 有现货 |
|
生物学信息
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产品名称PNU-282987
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems.
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产品描述PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems.
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体外实验PNU-282987 (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit.PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner.Animal Model:Rats Dosage:1, 3 mg/kg Administration:i.v.Result:Significantly reversed amphetamine-induced gating deficit.
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体内实验PNU-282987 (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a Ki of 27 nM.PNU-282987 has α7 nAChR agonist activity with an EC50 of 154 nM.PNU-282987 also has inhibition for the 5-HT3 receptor with an IC50 value of 4541nM.
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同义词———
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通路Others
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靶点Other Targets
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受体5-HT Receptor
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研究领域———
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适应症———
化学信息
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CAS Number123464-89-1
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分子量301.21
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分子式C14H18Cl2N2O
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纯度>98% (HPLC)
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溶解度?H2O : 50 mg/mL (166.00 mM; ultraphonic) DMSO : 10 mg/mL (33.20 mM; ultraphonic (<60°C)
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SMILESCl.C1CN2CCC1[C@H](C2)NC(=O)c1ccc(cc1)Cl
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化学全称Cl.C1CN2CCC1[C@H](C2)NC(=O)c1ccc(cc1)Cl
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Alice L Bodnar, et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem?
产品手册
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