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PARP1-IN-5 dihydrochloride?
CAS No. 2823308-89-8
PARP1-IN-5 dihydrochloride? ( —— )
产品货号. M37639 CAS No. 2823308-89-8
PARP1-IN-5 dihydrochloride 是一种低毒、具有口服活性、有效的和有选择性的 PARP-1 抑制剂(IC50 =14.7 nM)。PARP1-IN-5 dihydrochloride 可用于癌症研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1853 | 有现货 |
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| 10MG | ￥2993 | 有现货 |
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| 25MG | ￥4622 | 有现货 |
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| 50MG | ￥6501 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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| 1 mL x 10 mM in DMSO | ￥2328 | 有现货 |
|
生物学信息
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产品名称PARP1-IN-5 dihydrochloride?
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PARP1-IN-5 dihydrochloride 是一种低毒、具有口服活性、有效的和有选择性的 PARP-1 抑制剂(IC50 =14.7 nM)。PARP1-IN-5 dihydrochloride 可用于癌症研究。
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产品描述PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.
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体外实验PARP1-IN-5 dihydrochloride (0.1~10 μM; A549 cells) can significantly increase the cytotoxicity of CBP on A549 cells in a dose-dependent manner. PARP1-IN-5 dihydrochloride (0.1~10 μM; SK-OV-3 cells) decreases the expressions of MCM2-7. PARP1-IN-5 dihydrochloride (0.1~320 μM; A549 cells) has little cytotoxic effects on A549 cells. PARP1-IN-5 dihydrochloride (SK-OV-3 cells) can significantly decrease the PAR level.PARP1-IN-5 dihydrochloride exerts antitumor effects through PARP-1. PARP1-IN-5 dihydrochloride could increase the γ-H2AX expression.
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体内实验PARP1-IN-5 dihydrochloride (1000 mg/kg; p.o.) shows that there is no significant difference in the body weight and blood routine.PARP1-IN-5 dihydrochloride (25 and 50 mg/kg; p.o.; 12 days) significantly enhances the inhibitory effect of carboplatin on A549 cells at 50 mg/kg.PARP1-IN-5 dihydrochloride (50 mg/kg; p.o.) positively correlates with the expression of PARP-1.PARP1-IN-5 dihydrochloride can upregulate the expression of γ-H2AX and decrease the expression of PAR.Animal Model:Mice Dosage:1000 mg/kg Administration:P.o.Result:There was no significant difference in the body weight and blood routine.Animal Model:Mice Dosage:25 and 50 mg/kg Administration:P.o.; 12 days Result:Significantly enhanced the inhibitory effect of CBP on A549 cells at 50 mg/kg.Animal Model:Male Sprague?Dawley (SD) rats Dosage:50 mg/kg (Pharmacokinetic Analysis)Administration:P.o.Result:Positively correlated with the expression of PARP-1.
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同义词——
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通路Cell Cycle/DNA Damage
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靶点PARP
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受体PARP
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研究领域——
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适应症——
化学信息
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CAS Number2823308-89-8
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分子量537.46
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分子式C25H26Cl2N2O5S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 125 mg/mL (232.58 mM; 超声助溶 ) H2O 中的溶解度 : 1 mg/mL (1.86 mM; 超声助溶 (<60°C))
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SMILESO=C1C=C(C2=CC=C(O)C=C2)OC3=C(CN4CCN(CC5=CC=CS5)CC4)C(O)=CC(O)=C31.Cl[H].Cl[H]
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Long H, et al. Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer. J Med Chem. 2021;64(16):12089-12108.?
产品手册
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