TWIK-1/TREK-1-IN-3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TWIK-1/TREK-1-IN-3 (compound 2h) 是 TWIK 相关钾通道 (Potassium Channel) TREK-1 的抑制剂。TREK-1 含有双孔域钾 (K2p) 通道，二聚化为 TREK-1 同二聚体和 TWIK-1/TREK-1 异二聚体，是抗抑郁的重要靶点。TWIK-1/TREK-1-IN-3 靶向 TREK-1 同二聚体和 TWIK-1/TREK-1 异二聚体的 IC50s 分别为 9.74 μM 和 16.5 μM，具有抗抑郁样作用。

TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects.

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Cell Cycle/DNA Damage

Potassium Channel

Potassium Channel

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1440532-33-1

372.43

C19H27F3N2O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 25 mg/mL (67.13 mM; 超声助溶 (<60°C)

C([C@@H](COC1=CC=C(C(F)(F)F)C=C1)O)N2CCC(CC2)N3CCCC3

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(-20℃)

With Ice Pack

≥ 2 years