PKC-theta 抑制剂是一种选择性 PKC-θ 抑制剂 (IC50:12 nM)。

Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

Palmitoylcarnitine chloride 是一种脂肪酸衍生的线粒体底物，通过影响促炎途径，Ca2+ 流入和 DHT 样作用，可选择性降低大肠和前列腺癌细胞的细胞存活率。