TRPA1-IN-2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TRPA1-IN-2 (compound 1) 是一种有效的口服活性 TRPA1 抑制剂，IC50 值为 0.04 μM。TRPA1-IN-2 显示出抗炎活性。

TRPA1-IN-2 (compound 1) is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM. TRPA1-IN-2 shows anti-inflammation activity.

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Animal Model:16-18 g, female BABL/c mice Dosage:90 mg/kg Administration:I.p.; for 7 days Result:Reduced the total number of white blood cells and eosinophils in BALF.Animal Model:160-180 g, SD male rats (asthmatic rats)Dosage:30 mg/kg Administration:I.p.; for 7 days Result:Significantly Sexually reduced lung inflammation area and airway inflammation score in asthmatic rats.

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Membrane Transporter/Ion Channel

TRP/TRPV Channel

TRP/TRPV Channel

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2415206-22-1

442.48

C24H25F3N4O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (226.00 mM; 超声助溶 )

C(=O)(C1(NC2=CC=C(C#N)C=C2)CCCC1)N3CCN(CC3)C4=CC=C(C(F)(F)F)C=C4

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(-20℃)

With Ice Pack

≥ 2 years