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Aducanumab
CAS No. 1384260-65-4
Aducanumab ( —— )
产品货号. M36802 CAS No. 1384260-65-4
Aducanumab (BIIB037) 是一种选择性靶向聚集的 β 淀粉样蛋白 (Aβ) 的人单克隆抗体。Aducanumab 显示出脑渗透性，能够用于阿尔茨海默病 (AD) 研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥4551 | 有现货 |
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| 10MG | ￥6346 | 有现货 |
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| 25MG | ￥9226 | 有现货 |
|
| 50MG | ￥12369 | 有现货 |
|
| 100MG | ￥16020 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Aducanumab
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Aducanumab (BIIB037) 是一种选择性靶向聚集的 β 淀粉样蛋白 (Aβ) 的人单克隆抗体。Aducanumab 显示出脑渗透性，能够用于阿尔茨海默病 (AD) 研究。
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产品描述Aducanumab (BIIB037) is a human monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). Aducanumab shows brain penetration, and can be used for Alzheimer's disease (AD) research.
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体外实验——
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体内实验Animal Model:9.5- to 15.5-month-old Tg2576 transgenic mice Dosage:0.3-30 mg/kg Administration:Intraperitoneal injection (i.p.), weekly, 6 months Result: Increased recruitment of Iba-1-positive microglia to Aβ plaques.Animal Model:18-month-old Tg2576 mice Dosage:10 mg/kg Administration:Intraperitoneal injection (i.p.), weekly, 6 months Result:Restored neurite baseline calcium to control levels.Decreased the number of neurites with elevated levels of calcium after 2 weeks.Decreased the percentage of cell bodies with calcium overload.Restored the levels of VILIP and SERCA to control levels.Increased the cell numbers of NR1 and NR2A.Animal Model:22-month-old transgenic Tg2576 mice Dosage:0.4-1 mg/mL Administration: Intracerebroventricular injection (ICV), 20 minResult:Decreased the number of amyloid plaque.Decreased the size of the remaining individual plaques.Reduced amyloid plaque burden.
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同义词——
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通路Membrane Transporter/Ion Channel
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靶点Beta Amyloid
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受体Beta Amyloid
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研究领域——
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适应症——
化学信息
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CAS Number1384260-65-4
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分子量
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分子式——
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sevigny J, et al. The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature. 2016 Sep 1;537(7618):50-6. ?
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