Ceftriaxone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ceftriaxone (Ro 13-9904 free acid) 是一种广谱 β-内酰胺类三代头孢菌素类抗生素，对多种革兰氏阴性菌和阳性菌有良好的抗菌活性。Ceftriaxone 是 GSK3β 的共价抑制剂，IC50 值为 0.78 mM。Ceftriaxone是 Aurora B 的抑制剂。Ceftriaxone具有抗炎、抗肿瘤和抗氧化活性。Ceftriaxone 可用于治疗细菌性感染和脑膜炎的研究。

Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities.Ceftriaxone can be used in the study of bacterial infections and meningitis.

Cell Viability Assay Cell Line:Astrocyte Concentration:100 μM Incubation Time:24 h Result:Improved cell viability and increased glutamate uptake after MPP+ expose.Western Blot Analysis Cell Line:Astrocyte Concentration: 100 μM Incubation Time:24 h Result:Enhanced GLT-1 and GFAP expression.Decreased the expression of p-p50、p-IKKα、p-Relb.

Animal Model:DGL-induced rat modelDosage:200 mg/kg Administration:i.p.Result:Reduced the BUN、Cr 、AST and ALT levels.Attenuated the MDA levels and enhanced GPx and CAT activities.Reduced the levels of IL-1β and TNF-α mRNA.Animal Model:PTZ-induced rat model Dosage:200, 400 mg/kg Administration:i.p. 60 min before to PTZ (70 mg/kg)Result:Both of the two ceftriaxone groups had lower spike percentages than the saline group.Significantly lower MDA levels and higher SOD activity in 200 and 400 mg/kg.

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Microbiology/Virology

Antifungal

Antifungal

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73384-59-5

554.58

C18H18N8O7S3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 31.25 mg/mL (56.35 mM; 超声助溶 (<60°C)

C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C3=CSC(N)=N3)=O)C2=O)(SCC1CSC=4N(C)NC(=O)C(=O)N4)[H]

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(-20℃)

With Ice Pack

≥ 2 years