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Glembatumumab vedotin
CAS No. 1182215-65-1
Glembatumumab vedotin ( —— )
产品货号. M36588 CAS No. 1182215-65-1
Glembatumumab vedotin (CDX-011) 是一种 ADC (Antibody-Drug Conjugates (ADCs))，包含针对糖蛋白 NMB (GPNMB) 的全人 IgG2 单克隆抗体 (CR011)，并通过蛋白酶敏感的 vc 接头与强效微管蛋白结合细胞毒剂 MMAE 偶联。Glembatumumab vedotin 具有强大的抗癌作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥11590 | 有现货 |
|
| 10MG | ￥15675 | 有现货 |
|
| 25MG | ￥22878 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Glembatumumab vedotin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Glembatumumab vedotin (CDX-011) 是一种 ADC (Antibody-Drug Conjugates (ADCs))，包含针对糖蛋白 NMB (GPNMB) 的全人 IgG2 单克隆抗体 (CR011)，并通过蛋白酶敏感的 vc 接头与强效微管蛋白结合细胞毒剂 MMAE 偶联。Glembatumumab vedotin 具有强大的抗癌作用。
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产品描述Glembatumumab vedotin (CDX-011) is an ADC (antibody-drug conjugates (ADCs)) comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects.
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体外实验Cell Viability Assay Cell Line:Osteosarcoma cell lines Concentration:1 μg/mL to 125 μg/mL Incubation Time:96 hours Result:Demonstrated osteosarcoma cytotoxic activity.
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体内实验Animal Model:Athymic mice (6-week-old) injected with human SK-MEL-2 and SK-MEL-5 melanoma cells Dosage:1.25 mg/kg, 2.5 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg, 40 mg/kg, 60 mg/kg, 80 mg/kg Administration:i.v.; every 4 days; for 16 days Result:Showed inhibition of tumor growth.
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同义词——
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通路Others
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靶点Other Targets
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受体Microtubule Associated | Antibody-Drug Conjugates (ADCs)
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研究领域——
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适应症——
化学信息
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CAS Number1182215-65-1
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分子量Approximatel 149.16 kDa
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分子式——
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Christopher H Keir, et al. The use of an antibody drug conjugate, glembatumumab vedotin (CDX-011), for the treatment of breast cancer. Expert Opin Biol Ther. 2012 Feb;12(2):259-63. ?
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