MAHMA NONOate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MAHMA NONOate 是 NO 供体。MAHMA NONOate 有效抑制胶原蛋白或 ADP 诱导的血小板聚集。

MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP.

MAHMA NONOate (0.1 nM-100 μM) dose-dependently inhibits platelet aggregation induced by either collagen or ADP.MAHMA NONOate shows inhibitory effects to pulmonary artery and platelet aggregation with log IC50 values of 7.18 and 6.16, respectively.

MAHMA NONOate (0.3-10 nmol/kg/min; i.v. once) shows both platelet inhibitory and vasodepressor effects in vivo.Animal Model:Male Wistar rats anaesthetised with pentobarbitone Dosage:0.3-10 nmol/kg/min Administration:Intravenous injection; 0.3-10 nmol/kg/min once Result:Dose-dependently decreased in mean systemic artery pressure and showd a more potent effect than GSNO. Caused dose-dependent inhibition of the response to 0.3 μM/kg ADP.

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Proteasome/Ubiquitin

Endogenous Metabolite

Endogenous Metabolite | NO Synthase

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146724-86-9

204.27

C8H20N4O2

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 62.5 mg/mL (305.97 mM; adjust pH to 10 with NaOH)

O=NN(O)N(C)CCCCCCNC

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(-20℃)

With Ice Pack

≥ 2 years