Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.

Isovitexin 具有潜在的抗氧化活性，具有很强的降血糖作用，可抑制体内 α-葡萄糖苷酶。

LOXO-101（ARRY-470，Larotrectinib）是一种有效的选择性泛 TRK 抑制剂，针对 TRKA、TRKB 和 TRKC 激酶的细胞 IC50 为 2-20 nM。