MTK458

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MTK458 是一种具有口服活性的，脑渗透 PINK1 激活剂。MTK458 与 PINK1 结合并稳定活性异复合体，从而增加线粒体自噬。MTK458 可用于帕金森病的研究。

MTK458 is an orally active brain penetrant PINK1 activator. MTK458 binds to PINK1 and stabilizes an active heterocomplex, thereby increasing mitophagy. MTK458 can be used for research on Parkinson's disease.

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Animal Model:Stratum of mice injected with α-synuclein preformed fibrils (PFFs) Dosage:50 mg/kg Administration:Oral gavage (p.o.), daily, 6 months Result:Rescued an activity deficit in freely moving PFF mice.Reduced the levels of inflammatory markers (TREM2, IL-6, and CXCL1).Animal Model:C57BL6J wildtype mice injected with PFF Dosage:50 mg/kg Administration:Oral gavage (p.o.); 7 days, 3 weeks Result:Decreased pUb in the brain and plasma of PFF seeded mice.

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Others

PTEN

PTEN

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2499962-58-0

332.32

C17H15F3N4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (300.91 mM; 超声助溶 )

N(C1=C2C(NC(C(F)(F)F)=C2)=NC=N1)[C@H]3C=4C(CCC3)=CC=CC4

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(-20℃)

With Ice Pack

≥ 2 years