Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body\'s salt and water balance. Improves heart function.

Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-kappaB activation.

ML382 是一种有效的、选择性的 MrgX1 正变构调节剂（EC50 : 190 nM）。ML382 增强 BAM8-22 抑制高压激活的 Ca2+ 通道并减弱脊髓伤害性传导的能力，BAM8-22 和 ML382 均能有效减弱诱发的伤害性传导，持续的、自发的疼痛，不会引起明显的副作用。