TH1760

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TH1760 是一种 NUDIX-type 15 (NUDT15) 抑制剂，IC50 值为 25 nM。TH1760 通过增强核酸中 6-thio-(d) GTP 的积累使细胞对 6-硫代鸟嘌呤敏感。TH1760 增强了硫基嘌呤的抗白血病作用。

TH1760 is an inhibitor of NUDIX-type 15 (NUDT15) with an IC50 value of 25 nM. TH1760 sensitizes cells to 6-thioguanine by enhancing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 enhances the anti-leukemia effect of thiopurine.

Western Blot Analysis Cell Line:HCT116 cells.Concentration:10 μM.Incubation Time:4 h.Result:Inhibited the expression of NUDT15.Western Blot Analysis Cell Line:AML HL-60 cells.Concentration:10 μM.Incubation Time: 3 h.Result:Significantly inhibited the expression of NUDT15 when the temperature was higher than 54℃.

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Others

Other Targets

NUDIX hydrolase

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2567914-01-4

426.45

C20H18N4O5S

>98% (HPLC)

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S(=O)(=O)(C=1C=C2C(=CC1)NC(=O)O2)N3CCN(C(=O)C=4C=C5C(=CC4)NC=C5)CC3

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(-20℃)

With Ice Pack

≥ 2 years