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Uplarafenib
CAS No. 1425485-87-5
Uplarafenib ( —— )
产品货号. M35714 CAS No. 1425485-87-5
Uplarafenib (B-Raf IN 10) 是一种 BRAF 抑制剂，IC50 在 50-100 nM。Uplarafenib 具有抗肿瘤活性。是是
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1834 | 有现货 |
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| 10MG | ￥2689 | 有现货 |
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| 25MG | ￥4269 | 有现货 |
|
| 50MG | ￥6008 | 有现货 |
|
| 100MG | ￥7821 | 有现货 |
|
| 200MG | ￥10530 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥2024 | 有现货 |
|
生物学信息
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产品名称Uplarafenib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Uplarafenib (B-Raf IN 10) 是一种 BRAF 抑制剂，IC50 在 50-100 nM。Uplarafenib 具有抗肿瘤活性。是是
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产品描述Uplarafenib (B-Raf IN 10) (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. Uplarafenib shows antitumor activity.
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体外实验Uplarafenib (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E.Uplarafenib shows an IC50 between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E.Uplarafenib (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells.Cell Viability Assay Cell Line:A375, SK-MEL-28, SK-MEL-31 and CHL-1 Concentration:Incubation Time:72 h Result:Showed inhibition with IC50s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.
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体内实验——
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同义词——
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通路MAPK/ERK Signaling
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靶点Raf
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受体Raf
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研究领域——
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适应症——
化学信息
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CAS Number1425485-87-5
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分子量494.49
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分子式C22H21F3N4O4S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (202.23 mM; 超声助溶 (<60°C)
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SMILESCCCS(=O)(=O)Nc1cc(F)c(F)c(C(=O)c2ccc3ncc(nc3c2)N2CCOCC2)c1F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Yong-Liang Zhu, et al. Certain Chemical Entities, Compositions, and Methods. Patent US20130053384 A1.
