CJJ300

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CJJ300 是一个转化生长因子-β (TGF-β) 抑制剂， IC50 值为 5.3 μM。CJJ300 通过阻断 TGF-β-TβR-I-TβR-II signaling complex 的形成来抑制 TGF-β signaling。

CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC50 of 5.3 μM. CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex.

CJJ300 disturbs protein-protein interactions and prevents TGF-β receptor dimerization (IC50 = 23.6 ± 5.8 μM).CJJ300 (0-80 μM, 2 h) inhibits the phosphorylation of intracellular mediators in the downstream TGF-β signaling pathways, and suppresses the expression of markers of EMT (epithelial-mesenchymal transition) without cytotoxicity.CJJ300 suppresses TGF-β induced cell migration.Western Blot Analysis Cell Line:Human A549 lung epithelial cells Concentration:20, 40, and 80 μM Incubation Time:2 h Result:Significantly attenuated the increasement of P-Smad2/Smad3, P-Erk1/2 and P-Akt induced by TGF-β. Down regulated the expression of EMT-associated proteins, including fibronectin, α-SMA and MMP-2 in a dose-dependent manner.

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Others

Other Targets

TGF-beta/Smad

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1807631-83-9

435.6

C30H33N3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (229.57 mM; 超声助溶 )

C(NC1=CC=CC=C1)C2=C(C)C(CNC3=CC=CC=C3)=C(C)C(CNC4=CC=CC=C4)=C2C

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(-20℃)

With Ice Pack

≥ 2 years