MK-0159
CAS No. 2641484-61-7
MK-0159 ( —— )
产品货号. M35606 CAS No. 2641484-61-7
MK-0159 是一种具有口服活性的和选择性的 CD38 抑制剂,对人、小鼠和大鼠 CD38 的 IC50 分别为 22、3 和 70 nM。MK-0159 对人和啮齿动物的肝脏微粒体也显示出良好的稳定性。MK-0159 增加全血和心脏的 NAD+(烟酰胺腺嘌呤二核苷酸),降低 ADPR (二磷酸腺苷核糖)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ¥758 | 有现货 |
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| 5MG | ¥1264 | 有现货 |
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| 10MG | ¥1881 | 有现货 |
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| 25MG | ¥3646 | 有现货 |
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| 50MG | ¥5292 | 有现货 |
|
| 100MG | ¥6957 | 有现货 |
|
| 500MG | ¥13770 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MK-0159
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述MK-0159 是一种具有口服活性的和选择性的 CD38 抑制剂,对人、小鼠和大鼠 CD38 的 IC50 分别为 22、3 和 70 nM。MK-0159 对人和啮齿动物的肝脏微粒体也显示出良好的稳定性。MK-0159 增加全血和心脏的 NAD+(烟酰胺腺嘌呤二核苷酸),降低 ADPR (二磷酸腺苷核糖)。
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产品描述MK-0159 is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart.
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体外实验——
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体内实验Animal Model:Cardiac I/R injury miceDosage:30 mg/kg Administration:p.o.Result:Reduced infarct size, and the combination of MK-0159 and NAD+ precursor significantly reduced the infarct size compared to MK-0159 alone.Increased whole heart NAD+ levels and decreased ADPR in the heart.
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同义词——
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通路Others
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靶点Other Targets
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受体CD38
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研究领域——
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适应症——
化学信息
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CAS Number2641484-61-7
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分子量400.495
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分子式C20H24N4O3S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (249.69 mM; 超声助溶 )
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SMILESCOCCO[C@H]1CC[C@@H](CC1)NC(=O)c1cc(nc2[nH]ccc12)-c1cncs1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lagu B, et al. Orally Bioavailable Enzymatic Inhibitor of CD38, MK-0159, Protects against Ischemia/Reperfusion Injury in the Murine Heart. J Med Chem. 2022 Jun 28. ?
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