5-HT6/7 antagonist 1 ( —— )

产品货号. M35592 CAS No. 131999-28-5

5-HT6/7 antagonist 1是多功能的 5-HT6/7/2A 和D2 受体拮抗剂，但不与M1受体和hERG通道相互作用。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥11970	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

5-HT6/7 antagonist 1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

5-HT6/7 antagonist 1是多功能的 5-HT6/7/2A 和D2 受体拮抗剂，但不与M1受体和hERG通道相互作用。
产品描述

5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A andD2 receptors, without interacting with M1 receptors and hERG channels.
体外实验

Targeting 5-HT6 and/ or 5-HT7 receptors with antagonist drugs could constitute a promising strategy for treating symptoms of BPSD while avoiding some of the side effects of current antipsychotic drugs. Nevertheless, due to the complex pathology of dementia and accompanying behavioral and psychological symptoms, it seems unlikely that focusing on a single therapeutic target would be sufficient to provide adequate clinical benefit, and it is likely that successful development of novel anti-BPSD agents should involve a “designed” multifactorial approach..
体内实验

——
同义词

——
通路

GPCR/G Protein
靶点

Dopamine Receptor
受体

Dopamine Receptor | 5-HT Receptor
研究领域

——
适应症

——

化学信息

CAS Number

131999-28-5
分子量

393.41
分子式

C22H20FN3O3
纯度

>98% (HPLC)
溶解度

——
SMILES

FC=1C=C2C(C(=NO2)C3CCN(CCN4C(=O)C=5C(C4=O)=CC=CC5)CC3)=CC1
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Ko?aczkowski M, et al. Novel arylsulfonamide derivatives with 5-HT?/5-HT? receptor antagonism targeting behavioral and psychological symptoms of dementia. J Med Chem. 2014 Jun 12;57(11):4543-57.?

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册