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DHFR-IN-4
CAS No. 2820126-49-4
DHFR-IN-4 ( —— )
产品货号. M35563 CAS No. 2820126-49-4
DHFR-IN-4 是一种有效的二氢叶酸还原酶 (DHFR) 抑制剂IC50 为 123 nM。DHFR-IN-4 对 EGFR 和 HER2 也具有抑制活性，IC50 分别为 246 nM 和 357 nM。DHFR-IN-4 对癌细胞具有显著的广谱细胞毒性活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3287 | 有现货 |
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| 10MG | ￥4589 | 有现货 |
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| 25MG | ￥6417 | 有现货 |
|
| 50MG | ￥8984 | 有现货 |
|
| 100MG | ￥10980 | 有现货 |
|
| 200MG | ￥14850 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称DHFR-IN-4
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DHFR-IN-4 是一种有效的二氢叶酸还原酶 (DHFR) 抑制剂IC50 为 123 nM。DHFR-IN-4 对 EGFR 和 HER2 也具有抑制活性，IC50 分别为 246 nM 和 357 nM。DHFR-IN-4 对癌细胞具有显著的广谱细胞毒性活性。
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产品描述DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with an IC50 value of 123 nM. DHFR-IN-4 also has inhibitory activity against EGFR and HER2 with IC50s of 246 nM and 357 nM, respectively. DHFR-IN-4 has remarkable broad spectrum cytotoxic potency against cancer cells.
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体外实验DHFR-IN-4 (compound 42) (0-100 μM; 72 h) shows remarkable broad spectrum cytotoxic potency against HepG2, MCF-7, HCT-116, PC3 and HeLa.Cell Cytotoxicity Assay Cell Line:HepG2, MCF-7, HCT-116, PC3 and HeLa Concentration:0-100 μM Incubation Time:72 h Result:Exhibited antiproliferative activity against HepG2, MCF-7, HCT-116, PC3 and HeLa with IC50s of 9.67±0.7 μM, 8.46±0.7 μM, 13.24±0.9 μM, 11.17±1.0 μM and 6.90±0.5 μM.
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体内实验——
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同义词——
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通路Cell Cycle/DNA Damage
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靶点DHFR
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受体DHFR
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研究领域——
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适应症——
化学信息
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CAS Number2820126-49-4
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分子量371.46
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分子式C18H21N5O2S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(NN)C1=CSC2=NC(=C(C=3C=CC(=CC3)C)N21)CN4CCOCC4
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sabry MA, et al. New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity. Eur J Med Chem. 2022 Aug 10;241:114661.?
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